One thing that is totally annoying about Windows sleep mode is that so many applications crash or wont run right after you wake the computer back up. Adobe Creative Cloud (Photoshop, Indesign, Illustrator, etc) and Spotify are great examples of programs I have to end task on and then reopen. :/ I used to always shutdown my computer, but realized it was just a nice timesaver by keeping the computer on and letting it go to sleep. Although it does use more energy (not a lot as it shuts things down), but I dont have to reopen programs to get back to my last stopping point.
Often times the sound on my computer is all cracklely or static sounding. However, I did find out the way to fix that was to disable it and reenable it.